Cobalamin-folate interrelations [letter]
نویسندگان
چکیده
منابع مشابه
Cobalamin-folate interrelations: a critical review.
. cobalamin . + homocysteine p H4PteGlu + methionine. In the absence of cobalamin the reaction is impaired, the methyl group remains on tetrahydrofolate (H4PteGlu), and a critical lack of free tetrahydrofolate develops. As a result, single-carbon units such as formate and methylene cannot be taken up because of lack of a folate acceptor and synthesis of purines requiring formate, and that of th...
متن کاملMegaloblastic anaemia, cobalamin, and folate.
Developments relating to cobalamin and folate are reviewed. Current work on the relations between these two coenzymes are discussed, particularly those that have emerged in studies using nitrous oxide, which inactivates cobalamin.
متن کاملUpdate on cobalamin, folate, and homocysteine.
Three topics affecting cobalamin, folate, and homocysteine that have generated interest, activity, and advances in recent years are discussed. These are: (I). the application of an expanded variety of tools to the diagnosis of cobalamin deficiency, and how these affect and are affected by our current understanding of deficiency; (II). the nature of the interaction between homocysteine and vascu...
متن کاملHow I treat anemia in pregnancy: iron, cobalamin, and folate.
Anemia of pregnancy, an important risk factor for fetal and maternal morbidity, is considered a global health problem, affecting almost 50% of pregnant women. In this article, diagnosis and management of iron, cobalamin, and folate deficiencies, the most frequent causes of anemia in pregnancy, are discussed. Three clinical cases are considered. Iron deficiency is the most common cause. Laborato...
متن کاملCobalamin and folate binding proteins in human tumour tissue.
The serum of an 84 year old man with disseminated carcinoma was found to contain extremely high concentrations of cobalamin and of a cobalamin binding protein with trans-cobalamin I characteristics. Tumour tissue samples obtained at necropsy contained considerably higher concentrations of cobalamin binding protein (R-binder) than normal tissues. Tumour tissues also contained increased concentra...
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ژورنال
عنوان ژورنال: Blood
سال: 1987
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v69.3.974.bloodjournal693974